What is the difference between Botox and Fillers? This is a very common question posed to many of the top facial plastic surgeons as well as any cosmetic surgeon. In my practice, I get asked this question at least once a week. Although it may seem complicated, there is only one thing in common between Botox and Fillers like Juvederm or Esthelis; they both can treat wrinkles. Apart from that, questions like, “how Botox and Fillers work?” “how long they last?” and “where can you use them on your face?” are different.